phosphoinositide 3-kinase — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T4219	Autophinib		PI3K , Autophagy
	Autophinib is a potent autophagy inhibitor with a novel chemotype with IC50 values of 90 and 40 nM for autophagy in starvation induced autophagy assay and rapamycin induced autophagy assay.		PI3K , Autophagy
T4S1796	Heterophyllin B		PI3K
	Heterophyllin B effectively suppresses the adhesion and invasion of the human esophageal carcinoma cells by mediating the PI3K/AKT/β-catenin pathways and regulating the expression levels of adhesion- and invasion-associa...		PI3K
T9460	IMDK		PI3K
	iMDK quarterhydrate is a potent PI3K inhibitor that inhibits the growth factor MDK (also known as midkine or MK). iMDK quarterhydrate synergistically inhibits non-small cell lung cancer (NSCLC) with MEK inhibitors withou...		PI3K
T6677	Sophocarpine		ERK , p38 MAPK , NF-κB , TLR , COX , HER , JNK , STAT
	Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.		ERK , p38 MAPK , NF-κB , TLR , COX , HER , JNK , STAT
TN1134	Euscaphic acid		Apoptosis , LDL , PI3K , DNA/RNA Synthesis , NO Synthase , Prostaglandin Receptor
	Euscaphic acid has anti-diabetic, and anti-inflammatory activities, it inhibits LPS-induced inflammatory responses by interference with the clustering of TRAF6 with IRAK1 and TAK1, resulting in blocking the activation of...
T2836	Isorhamnetin	3-methylquercetin,3'-Methylquercetin,Isorhamnetol,3'-Methoxyquercetin	MEK , PI3K , Endogenous Metabolite
	Isorhamnetin (3-methylquercetin) is the methylated metabolite of quercetin. Quercetin is an important dietary flavonoid with in vitro antioxidant activity. Isorhamnetin prevents endothelial cell injuries from oxidized LD...		MEK , PI3K , Endogenous Metabolite
T2619	CH5132799		PI3K , mTOR
	CH5132799 has been used in trials studying the treatment of Solid Tumors.		PI3K , mTOR
T15592	IPI-3063		PI3K
	IPI-3063 is an effective and selective inhibitor of PI3K p110δ (IC50: 2.5 ± 1.2 nM).		PI3K
T2418	A66		PI3K
	A66 is a specific and effective p110α inhibitor(IC50=32 nM).		PI3K
T6208	AS-252424		Casein Kinase , PI3K
	AS-252424 is a potent and selective inhibitor of PI3Kγ with IC50 of 33 nM; >10 fold selectivity for PI3Kγ versus PI3Kα.		Casein Kinase , PI3K
T6757	AMG319		PI3K
	AMG319 is a potent and selective PI3Kδ inhibitor with IC50 of 18 nM, >47-fold selectivity over other PI3Ks. Phase 2.		PI3K
T2672	TG100-115		PI3K
	TG100-115 is a PI3Kγ/δ inhibitor (IC50: 83/235 nM), with fewer effects on PI3Kα/β.		PI3K
T22377	NIBR-17		PI3K
	NIBR-17 is a pan class I PI3K inhibitor. NIBR-17 inhibits PI3KKα, PI3KKβ, PI3KKγ, and PI3KKδ with IC50 of 1 nM, 9.2 nM, 9 nM, and 20 nM respectively.		PI3K
T6773	AZD8186		PI3K
	AZD8186 is an effective and specific PI3Kβ/δ inhibitor (IC50: 4/12 nM).		PI3K
TQ0229	ETP-46321		PI3K
	ETP-46321 is an effective and orally bioavailable PI3Kα/PI3Kδ inhibitor (Ki: 2.3/14.2 nM).		PI3K
T1949	CZC24832		PI3K
	CZC24832 is a selective inhibitor of PI 3-kinase γ.		PI3K
T13386	Zandelisib		PI3K
	Zandelisib is an inhibitor of phosphatidylinositol 3-kinase (PI3K)(p110δ, IC50 of 3.5 nM), and with antineoplastic activity.		PI3K
T3348	PIK-293	PIK293	PI3K
	PIK-293 is a PI3K inhibitor, for PI3Kδ( IC50=0.24 μM), and less potent for PI3Kα/β/ γ.		PI3K
T6168	ZSTK474		PI3K , Autophagy
	PI3K Inhibitor ZSTK474 is an orally available, s-triazine derivative, ATP-competitive phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity.		PI3K , Autophagy
T6433	CAY10505		Apoptosis , PI3K
	CAY10505, a form of dehydroxyl of AS-252424, is a PI3Kγ inhibitor (IC50: 33 nM).		Apoptosis , PI3K